William E. Hopkins, MD, FACC

Education:

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Residency

Fellowship

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Biography:

Dr. Hopkins is the Director of the Adult Congenital Heart Disease and Pulmonary Hypertension Program and the Adult Down Syndrome Program at the University of Vermont College of Medicine. He is an expert in the diagnosis and treatment of valvular heart disease and heart disease associated with liver disease. He has a research interest in Eisenmenger Syndrome, cyanotic congenital heart disease, and pulmonary hypertension. In addition to many academic awards, Dr. Hopkins has been the recipient of prestigious teaching honors, including the Foundations Teaching Award from the University of Vermont College of Medicine and is a five time recipient of the E.L. Amidon Award for Teaching Excellence from the Department of Medicine. He is the member of several professional organizations as well as an associate editor of Coronary Artery Disease.  He has published and lectured widely, and written book chapters on medical management of congenital heart disease in adults, pulmonary hypertension and cardiac disease in patients with diabetes mellitus. Dr. Hopkins makes his home in Shelburne and is a native of Illinois.

Major Research Interests:

In addition to providing comprehensive care to patients and their families, Dr. Hopkins is committed to advancing knowledge in the fields of congenital heart disease, pulmonary hypertension, and genetic heart disease.  His research focuses on the unique physiology of cyanotic congenital heart disease in adults, the relationship between chronic hypoxia and natriuretic peptides, the relationship between pulmonary hypertension and chronic hepatitis C infections, and vascular protection in adults with Down syndrome.

Publications:

Representative Publications from a total of 30

Hopkins, W. E., Waggoner, A. D.  Right and Left Ventricular Area and Function Determined by Two-Dimensional Echocardiography in Adults With the Eisenmenger Syndrome from a Variety of Congenital Anomalies.  Am J Cardiol 1993;72:90-94.

Hopkins, W.E., Waggoner, A.D., Gussak, H. Quantitative Ultrasonic Tissue Characterization of Myocardium in Cyanotic Adults With an Unrepaired Congenital Heart Defect. Am J Cardiol 1994;74:930-934.

Hopkins, W.E., Waggoner, A.D.  Pulsed Doppler Echocardiographic Evidence of Impaired Left Ventricular Filling in Cyanotic Adults With Nonrestrictive Ventricular Septal Defects With and Without Pulmonary Vascular Obstructive Disease. Am J Cardiol 1995,76:526-527.

Hopkins, W.E., Ochoa, L.L., Richardson, G.W., Trulock, E.P. Severe Pulmonary Artery Hypertension:  A Comparison of Hemodynamics and Survival of Adults With Primary Pulmonary Hypertension or Eisenmenger Syndrome. J Heart Lung Transplant; 1996;15:100-105.

Hopkins, W.E., Kelly, D.P.  Usefulness of Angiotensin Converting Enzyme Inhibitors in Adults with Cyanotic Congenital Heart Disease. Am J Cardiol 1996,77:439-440.

Hopkins, W.E., Hall, C.  Paradoxical Relationship Between N-Terminal Proatrial Natriuretic Peptide and Filling Pressure in Adults with Cyanotic Congenital Heart Disease Circulation 1997; 96:2215-2220.

Hopkins, W. E., Sobel, B.E., Schneider, D. J.  Plasminogen Activator Inhibitor Type 1 in Adults with Down Syndrome and Protection Against Macrovascular Disease. Am J Cardiol 2000,85:784-786.

Hopkins, W.E., Waggoner, A.D.  Severe Pulmonary Hypertension without Right Ventricular Failure: The Unique Hearts of Patients with the Eisenmenger Syndrome. Am J Cardiol 2002;89::34-38.

Hopkins, W.E., Chen, Z., Fukagawa, N., Hall, C., Knot, H., LeWinter, M.: Increased Atrial and Brain Natriuretic Peptides in Adults with Cyanotic Congenital Heart Disease: Enhanced Understanding of the Relationship Between Hypoxia and Natriuretic Peptide Secretion. Circulation 109:2872-2877, 2004.

Hopkins, W.E. The Remarkable Right Ventricle of Patients with Eisenmenger Syndrome.  Coronary Artery Disease 2005; 16:19-25.