Research
Major Research Interests
Dr. Ken Brown has published extensively in the field of nuclear cardiology as a principle investigator for original research studies as well as in reviews, editorials and textbooks.
His seminal observations demonstrated that nuclear imaging results predict future cardiac events. Dr. Brown has been a major contributor to the literature that has established the clinical utility of nuclear myocardial perfusion imaging for defining cardiac risk in patients with known or suspected coronary artery disease. These results have had a major impact on the practice of cardiology by enhancing the ability of physicians to select those patients who should be evaluated with invasive procedures and considered for revascularization.
Dr. Brown's ongoing research interests include the use of nuclear imaging to identify high and low risk patients treated with implantable defibrillators, the use of an adenosine challenge test to determine the vasodilator responsiveness of patients recently exposed to caffeine, and the use of nuclear imaging to identify patients with diabetes mellitus who are at risk for restenosis, progression of disease and future cardiac events following coronary revascularization.
Major Current Grant Support
Bristol Myers Squibb Pharmaceutical Company
Principle Investigator, Chair Writing Committee: "A Phase IV Open-Label, Randomized, Multi-Center Trial To Evaluate The Ability Of Technetium 99m Sestamibi Stress Myocardial Perfusion Imaging To Detect Asymptmatic Restenosis In Diabetic Patients Who Have Undergone Percutaneous Coronary Intervention."
Bristol Myers Squibb Pharmaceutical Company
Support Grant 1999 - Principal Investigator: “Relationship of scar or ischemia defined by stress technetium 99m sestamibi imaging to risk of high grade ventricular arrhythmia in patients with automatic implantable cardiac defibrillators”.
Fujisawa Pharmaceutical Company
Support Grant 2003 - Assessment Of Responsiveness To Vasodilator Stress In Patients Exposed To Recent Caffeine Ingestion: Relationship Of Adenosine Challenge Sensitivity To Serum Caffeine Levels And Time From Ingestion
Representative Publications
Brown KA, Boucher CA, Okada RD, Guiney TE, Newell JB, Strauss HW, Pohost GM. Prognostic value of exercise thallium-201 imaging in patients presenting for evaluation of chest pain. J Am Coll Cardiol 1983; 1:994-1001.
Brown KA, O’Meara JR, Chambers CE, Plante DA. Ability of dipyridamole-thallium-201 imaging 1-4 days after acute myocardial infarction to predict in-hospital and late recurrent myocardial ischemic events. Am J Cardiol 1990; 65:160-167.
Brown KA. Prognostic value of thallium-201 myocardial perfusion imaging: A diagnostic tool comes of age. Circulation 1991; 83:363-381.
Brown KA. Prognostic value of thallium-201 myocardial perfusion imaging in patients with unstable angina who respond to medical treatment. J Am Coll Cardiol 1991; 17:1053-1057.
Brown KA, Rowen M. Extent of jeopardized viable myocardium determined by myocardial perfusion imaging best predicts perioperative cardiac events in patients undergoing non-cardiac surgery. J Am Coll Cardiol 1993; 21:325-330.
Brown KA, Heller GV, Landin RJ, Shaw LJ, Beller GA, Pasquale MJ, Haber SB. Early Dipyridamole Tc99m-sestamibi SPECT imaging 2-4 days after acute myocardial infarction predicts in-hospital and post-discharge cardiac events: comparison with submaximal exercise imaging. Circulation 1999; 100:2060-2066.
Rodgers GP, Ayanian JZ, Balady G, Beasley JW, Brown KA, Gervino EV, Paridon S, Quinones M, Schlant RC. American College of Cardiology/American Heart Association/American College of Physicians Clinical Competency Statement on Stress Testing. Circulation 2000; 102:1726-38.
Brown KA. Risk assessment in CAD: Suspected CAD/Known Stable CAD. In: Iskandrian AE, Verani MS. Nuclear Cardiac Imaging Principles and Applications, 3rd Edition. Oxford University Press, New York, 2003.
Brown KA. Nuclear Cardiology Techniques in Acute Coronary Syndromes. In: Theroux P. Acute Coronary Syndromes: A Companion to Braunwald’s Heart Disease. Saunders Publishing, Philadelphia, 2003.
Brown, KA. Risk stratification: stress myocardial perfusion imaging. In: Rutherford-JD. 6th Adult Clinical Cardiology Self-Assessment Program of the American College of Cardiology (ACCSAP VI): Chronic coronary artery disease. American College of Cardiology, Bethesda, MD, 2004
Brown KA. Advances in nuclear cardiology: preoperative risk stratification. J Nucl Cardiol 2004; 11:335-348.
Brown KA. Risk Stratification In Acute Coronary Syndromes. In: Zaret BL, Beller GA. Clinical Nuclear Cardiology: State-Of-The-Art And Future Directions, 3rd Edition, in press
