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Infectious Disease Fellowship: Program Curriculum
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Contents:

First Year

During the first year, the trainee will have an in-depth education in clinical infectious diseases supplemented by infection control, hospital epidemiology, and hospital anti-infective formulary management.

The third month of training will be spent in the clinical microbiology/immunology laboratory. The month of January will be a laboratory research elective. The month of April will be another elective month.  The remaining nine months will be spent on the clinical infectious disease inpatient consultative service working with the six attendings on a rotating basis. The trainee will participate in the I.D. conferences, Journal club, clinical case conference, I.D. core curriculum of lectures, and research conference. The trainee will also spend a half day a week at the outpatient clinic.  During the latter part of the first year the trainee will begin to develop his/her research interests and goals for the second year.

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Second Year

The second year will be dedicated to research. The structure of the year will be based on the goals of the fellow. Research areas may be clinical (nosocomial infections, HIV epidemiology, pharmaceutical studies, HIV/AIDS, among others); clinical laboratory microbiology / immunology, or basic science research. During this year, the trainee can elect to have additional month long rotations in hospital infection control and clinical epidemiology, study public health and epidemiology with the Vermont Department of Health, take a month or more rotation in clinical pediatric infectious diseases, or participate in the rural HIV satellite clinic project. The fellow will spend 1 full day per week in the outpatient clinic. The trainee will participate in the I.D. conferences, Journal club, clinical case conference, I.D. core curriculum of lectures, and research conference.

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Microbiology and Immunology

The ID fellow will spend one month early in their first year in the clinical microbiology and immunology laboratory.

1. Goal: To learn basic microbiology and immunology that is applicable to the practicing infectious disease specialist

2. Objective: To introduce to fellow to the techniques of microbiologic identification, sensitivity testing and work up of mycobacteria, viruses, fungi and parasites. Basics concepts of immunology will be introduced. Microbial virulence factors and host defense mechanisms will be reviewed. The laboratory evaluation of the immune compromised host and serologic diagnosis of disease will be reviewed. Specific objectives of the rotation include:

Microbiology

  • specimen collection and handling
  • Gram stain preparation and review
  • work up of specimens
  • work up of unknown

3. Teaching environments: Working directly with the medical technologists, laboratory supervisors and medical directors, the fellow will gain hands on experience working up clinical samples for microbiologic identification and sensitivity testing. Rotations through the mycobacteriology, virology and mycology sections will introduce the fellow to culturing and identification techniques for these organisms. The fellow will also learn about parasitology identification and clinical molecular techniques. Daily rounds with the laboratory director to review specimens and work-ups in progress.

4. Mix of diseases: Bacteria, mycobacteria, viruses, parasites and fungi induced. Laboratory evaluation of the immune compromised host.

5. Reading list: Sections from the Principles and Practice of Infectious Diseases edited by Mandell concerning the clinician and the microbiology laboratory.

6. Evaluation: Written evaluation by the head of the clinical microbiology laboratory . The fellow will also provide written evaluations of the rotation to the fellowship director.

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In-Patient Rotation

The fellow will spend about 9 months on the clinical in-patient consultative rotation

1. Goals: To introduce the fellow to the fundamentals of infectious disease diagnosis and treatment for patients hospitalized with infections including elucidation of the infectious disease problems, clinical differential diagnosis of those problems, microbiology of the infections and approach to diagnosis and therapy. Diagnosis and care will be provided to patients with a wide array of infections and in all stages of illness.

2. Objectives:

Antimicrobial agents:

  • mechanisms of action
  • adverse reactions
  • drug monitoring
  • appropriate use and cost containment
  • home intravenous antibiotic management
  • chemoprophylaxis and immune prophylaxis

Specimen collection

  • lumbar puncture
  • abscess aspiration
  • paracentesis
  • arthrocentesis
  • wound and soft tissue culturing
  • handling bronchoscopy specimens

Clinical syndromes including:

  • upper respiratory tract infections
  • community and nosocomial pneumonia
  • pleural space infections
  • peritonitis
  • skin and soft tissue infections
  • intraabdominal and gastrointestinal infections
  • endometritis
  • bacteremia
  • urinary tract infections
  • post traumatic infections, wound infections
  • endophthalmitis, uveitis
  • bone and joint infections
  • endocarditis, pericarditis
  • soft tissue infections
  • central nervous system infections
  • catheter related infections
  • hepatitis
  • sepsis and septic shock
  • infections in the elderly
  • febrile patient in the intensive care unit
  • immune compromised host (neutropenia, transplantation, leukemia, lymphoma, immune suppressive agents)
  • post operative patient with infection
  • fever assessment and fever of unknown etiology
  • the pregnant patient with fever
  • patients with HIV/AIDS related infections
  • infections in the patient with IDU

3. Teaching environment:

Daily inpatient rounds with the ID attending. This includes review of the fellow's presentation, clinical bedside examination, review of all laboratory data and radiology tests. The fellow's assessment of the problems and plans are critiqued along with antibiotic management and written consult notes. Rounds generally last for 6-8 hours per day.

  • Antibiotic restriction program
  • Informal "curbside" consultations
  • Monthly conferences
  • Monthly lectures

4. Mix of diseases:

There are about 110 consults per month including those from medicine, general surgery, orthopaedics, neurosurgery, vascular surgery and ob-gyn. Patients with diseases in all categories listed above are seen.

5. Patient characteristics and types of clinical encounters, procedures and services:

  • Patients from all socioeconomic strata are seen
  • Patients and diseases as above
  • Lumbar puncture
  • Wound assessment and exploration
  • Gram stain

6. Reading list:

  • Mandell's text according to disease encountered
  • Core curriculum conference
  • Journal club
  • Case conference

7. Pathological material: Gram stains are reviewed on most patients. Pathological specimens can be reviewed with the pathology department as needed.

8. Evaluation: Immediate feedback on each patient presentation. Written evaluation by the ID attendings on service. The fellow will also provide written evaluations of the rotation to the fellowship director.

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Out-Patient Rotation and Continuity of Care

1. Goals: To introduce the fellow to the management of infectious diseases in the outpatient setting. A large part of this experience will be the HIV/AIDS continuity of care clinic. The first year fellow will receive the HIV (+) patients from the fellow completing his/her training and all new HIV (+) patients during the first year. The fellow will follow these patients throughout the two years of training. All levels of care including specialty and primary care are provided. The management of patients with general ID problems will also be taught to the first and second year fellows. Issues include medical care, psychosocial assessment, drug and alcohol abuse, end of life care, medical insurance issues and patient-physician relationships.

2. Objectives: Care of the patient with HIV/AIDS

  • immune evaluation
  • recognition and management of opportunistic infections
  • prophylactic agents, vaccinations
  • antiretroviral therapy and monitoring; viral loads, genotypes, phenotypes
  • sexually transmitted disease
  • drug adherence
  • psychosocial, alcohol and substance abuse assessment
  • hospice care
  • family support, confidentiality
  • pain management
  • management of substance abuse

Outpatient management of:

  • the patient with FUO
  • the febrile patient with immune compromise
  • infections in the injection drug user
  • the ill returning international traveler
  • the patient needing home intravenous antibiotic therapy
  • assessment and treatment of the patient with:                                                   
    • sexually transmitted diseases
    •  pneumonia, bronchitis
    • upper respiratory infection
    • urinary tract infections
    • acute and chronic diarrhea
    • viral hepatitis
    • osteomyelitis and septic arthritis
    • endocarditis
    • cellulitis
    • infectious diarrhea and parasites
    • lyme disease
    • line infections
    • fever and rash
    • parasities
    • mycobacteria infection
      • M.Tb
      • Atypical AFB
    • other viral infections
      • HSV, CMV, HPV

Antimicrobial agents:

  • adverse reactions
  • drug monitoring
  • appropriate use and cost containment
  • home intravenous antibiotic management

Chemoprophylaxis, immune prophylaxis, cytokines, colony stimulating factors, monoclonal antibodies

3. Teaching environment: An ID attending is present throughout clinic. Each patient is reviewed with the attending and history and physical examination confirmed at the bedside. Assessment, plans and dictated note are reviewed. The fellow will also interact with the clinic nurse practitioner, social worker and regional AIDS service organization.

  • Monthly conferences. See below
  • Monthly lectures. See below

4. Mix of diseases: As above

5. Patient characteristics and types of clinical encounters, procedures and services:

  • Patients of all socioeconomic strata and ethnic mix. 
  • Lumbar puncture and Gram stain

6. Reading list:

  • Mandell's text according to disease encountered
  • Journal club
  • Case conference
  • Medical Management of HIV Infection by John Bartlett and Joel Gallant

7. Pathological material: Gram stain and cultures

8. Evaluation: Immediate feedback on each patient presentation. Written evaluation by the ID attendings on service. The fellow will also provide written evaluations of the rotation to the fellowship director.

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Elective Months

The fellow will have two months of elective time during their first year. The timing of these months is to allow a change in venue from the more intense in-patient consultation rotation.

1. Goals: To provide more outpatient clinical ID, HIV/AIDS care and international travelers clinic experience, allow time to develop second year research project and introduce the process of quality assessment and cost containment activities.

2. Objectives:

Outpatient clinic. The fellow will work one-on-one with an ID attending during a full day of outpatient clinic. He/she will see 10-12 patients with varied infectious disease illness and HIV/AIDS. All patients will be assessed by the fellow and reviewed with the ID attending.

International travelers clinic. The fellow will work with the nurse practitioner and see patients four times per month. Travel itinerary, parasitic, bacterial, mycobacterial and viral risks, malaria prophylaxis and vaccinations will be reviewed for each patient.

Quality assessment (QA). QA can be performed by involvement in ongoing QA projects involving antibiotic utilization, HIV/AIDS care or hospital epidemiology. He/she will learn the fundamentals of continuous quality improvement (CQI). This program will entail developing goals and objectives for quality standards, developing data collection tools, chart review, data assessment and feedback to providers. Areas of QA that the fellow may participate in include;

  • Working with Dr. Grace and John Ahern of pharmacotherapy to design, implement and assess quality of antibiotic use. This is an ongoing program of the Infectious Disease Practice Committee (IDPC). Data is used to assess the hospital antibiotic formulary, quality of antibiotic use and to monitor costs.
  • Working with Kemper Alston on infection control projects. See below.
  •  Working with Dr. Grace, the clinic nurse practitioner and Eric Zelman (computer analyst for the HIV clinic program) to review HIV/AIDS care. The fellow would participate in the New York State HIVQUAL program that the HIV/AIDS clinic programs is participating in. 
  • Case and HIV/HCV conference
  • Department of Medicine morbidity and mortality conference

Research development. The fellow will spend part of the elective month deciding on and early planning for the second year research project

  • Meet with the six ID attendings to review ongoing and new projects.
  • Meet with researchers from Microbiology and Molecular Genetics to review ongoing projects
  • Begin background reading and hypothesis development

3. Teaching environment: 

  • Outpatient clinic with direct supervision by the ID attending and nurse practitioner 
  • Working with pharmacotherapy
  • International travelers computer program
  • Monthly conferences
  • Working with research mentor

4. Mix of diseases:

  • HIV/AIDS
  • General infectious diseases
  • Home intravenous therapy
  • International traveler

5. Patient characteristics and types of clinical encounters, procedures and services: as above

6. Reading list:

  • Mandell's text according to disease encountered
  • Medical Management of HIV Infection by John Bartlett and Joel Gallant
  • Article review conference
  • Journal club
  • Case conference

7. Pathological material: Gram stains and culture interpretation

9. Evaluation: Dr. Grace will review progress with each fellow at the end of the month. Written evaluation will be done. The fellow will also provide written evaluations of the rotation to the fellowship director.

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Hospital Epidemiology Course

1. Goals. Each fellow is enrolled in the Infectious Diseases of America (IDSA)/Society for Healthcare Epidemiology of America (SHEA) online infection control fellows' course.  The goal of the course is to give the fellows basic training about infection control and epidemiology.   

2. Objectives. The fellow will be introduced to concepts relating to identification of health care associated infections, antimicrobial resistant organisms, epidemiologically important organisms; review of epidemiology of these organisms; infection control practices and antibiotic management strategies; impact of these infections on patient safety.

3. Teaching environment:  This is a self study module taken online.  The course is presented as a series of lectures in audio form with accompanying power point slides.   The fellow can finish the course according to his/her own pace.

4. Evaluation: Pre- and post-tests are administered at the beginning and end of the course, respectively.  A certicate of completion will be issued upon completion of the course.

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Research Year

1. Goals: The goal of the research year is to develop, implement and complete a scientific research project so that the fellow can learn the basics of hypothesis development, design, protocol development and statistical analysis. The project can be clinically or basic science oriented. It is expected the results will be submitted to an infectious disease national meeting (IDSA or ICAAC). The current (and future) research efforts that the fellow can participate in include:

Clinical:

  • HIV epidemiology
  • Blood culture utilization
  • Enteric pathogen vaccine development
  • Risk factors for orthopaedic surgery infections
  • Clostridium difficile associated diarrhea
  • Staphylococcal enterocolitis
  • Nosocomial infections
  • Anal HPV infections    

Basic science:

  • Cryptosporidiosis mucosal immunology
  • HIV pathogenesis and ribozyme
  • Use of transgenic systems to develop novel anti-cryptosporidium drugs
  • Pathogenesis of amebic infections
  • Lyme borreliosis pathogenesis

2. Objectives:

The fellow will be introduced to: 

  • Hypothesis development and research design
  • Introduction to statistics
  • Regulations
  • Data collection and management
  • Data analysis

3. Teaching environment:

  • One-on one mentoring with ID attendings or basic science researcher
  • Research conference
  • Research seminars

4. Mix of diseases: Not applicable

5. Patient characteristics and types of clinical encounters, procedures and services: Depending on research developed

6. Reading list:

  • Designing Clinical research by Hulley SB & Cummings SR. 1988
  • Biostatistics; The Bare Essentials by Norman GR & Streiner DL

7. Pathological material: Not applicable

8. Evaluation: Feedback on day to day progress on the project. Written evaluation by the research mentor. The fellow will also provide written evaluations of the rotation to the fellowship director

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Conferences

1.  Core Curriculum Lecture Series

This is a weekly lecture series conducted by the ID attendinga and fellows reviewing key infectious disease topics. 

Goal:  To discuss various topics relevant to the practice of General Infectious Diseases. Topics include:

  • Microbiology and laboratory testing
  • Basics of immunology
  • Antibiotics
  • Clinical syndromes recognition, diagnosis and treatment

Objective:  To increase the fellows' knowledge base in General Infectious Diseases.

Frequency:  1 hour weekly (or two hours every other week)

Format:  Can either be a formal lecture, discussion on assigned readings, practice tests, or other teaching modalities deemed appropriate by the attending assigned.

Supervision:  An attending is assigned to conduct each session

Evaluation:  As part of the monthly written evaluation. 

 

2. Case Conference

This is a bimonthly conference attended by all ID attendings, microbiology staff, members from the Vermont Department of Health and members form the Microbiology and Molecular Genetics staff. Presenters include the fellows and ID attendings. There are several guest speakers each year.

Goal: To review the literature regarding specific infectious diseases, therapies, immunology and microbiology. Most often these will involve the diagnosis and management of infections seen in the inpatient consultation service or clinic.

Objective:

  • Learn critical review of the literature and how that applies to clinical practice
  • Review key topics of clinical infectious diseases and drug therapy
  • Improve oral presentation skills

Frequency:  Twice per month

Format:  Formal presentation of the case, literature review and typed handout

Supervision:  All six attendings are present and critique the fellow

Evaluation: As part of the monthly written evaluation

 

3. HIV/HCV conference

Goal: To review timely topics concerning HIV and HCV in order to remain current with these rapidly changing fields. Presenters include the fellows, ID attendings and nurse practitioner from the clinic.

Objective:

  • To remain current regarding protocols and guidelines
  • Update therapies
  • Review new insights into pathogenesis

Frequency: Once monthly

Format: Each one-hour session will have two presentors. Presentations can be article reviews, protocols or guideline updates or psychosocial topics. Difficult patient management issues can also be presented.

Supervision: All six attendings are present and critique the fellow

Evaluation: As part of the monthly written evaluation

 

4. Research Conference

Goal:  To introduce the fellow to ID unit research projects, other ID related research in the College of Medicine and assess progress on fellow's research project.

Objective: 

  • To review ongoing research activities of the ID unit
  • Introduce the fellow to research hypothesis, design, data collection and analysis
  • Critique new projects
  • Prepare for national meeting presentations
  • Review ID related research from other units and departments

Frequency: Monthly

Format: Each one hour conference will have a formal presentation of a research project of the fellow or attending including design, data collection and outcomes. Guest lectures will present current research topics or summary lectures concerning research techniques.

Supervision: All six attending are present and critique the fellow's presentation

Evaluation: For the fellow presenting his/her research, written evaluation is performed monthly by his/her research mentor.

 

5. Journal club

Goal: To critically review current infectious diseases articles

Objective: To assess

  • research design
  • data analysis
  • correlation with previous literature
  • discussion and outcomes

Frequency: Once monthly

Format:  Articles will be reviewed by the fellows and attendings

Supervision: All attendings attend the conference

Evaluation:  As part of their monthly written evaluation

 

6. Case Discussion

Goal: To discuss cases seen by the fellows and attendings in their practices

Objective:  To outline management issues on each of the cases and solicit approaches to the issues at hand from the attendees.  

Frequency: Once a month

Format:  Fellows and attendings informally present challenging cases from either the inpatient or outpatient setting.  The cases in mind will have specific issues that will be presented and the attendees will offer their approaches to the issues at hand.

Supervision:  All attendings attend the discussion

Evaluation:  As part of their monthly written evaluation

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Lectures

1. ID unit core lectures

These are lectures given by the inpatient ID consult attendings to the Infectious Disease consult team which is usually composed of a medical resident, a medical student, a pharmacy resident, and the ID fellow.

Goal: To introduce the team to general infectious disease topics such as HIV/AIDS, Endocarditis, Urinary Tract Infections, Skin and Soft tissue infections, Neutropenic fever, Antibiotics, among others.

Objective:  To discuss various infectious disease topics relevant to the members of the Infectious Disease consult team.

Frequency:  Four times per week

Format: Hour long didactic lecture or discussion

 

2. FAHC GME Core Competencies

Goal: To help the fellow become well rounded in patient care and clinical practice issues

Objective: Lectures will be given concerning:

  • Cultural diversity
  • Physician impairment and recovery
  • Clinical genetics
  • Ethics and end of life decisions
  • Errors in Medicine
  • Sizing up Medical Practice Business
  • Contract negotiations
  • Pain management
  • Domestic violence
  • Compliance

Frequency: Workshops scheduled quarterly

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